Unraveling the Reality: Exploring the True Story Behind Netflix’s ‘Painkiller


“Painkiller,” a gripping six-part drama, delves into the harrowing impact of the opioid epidemic, shedding light on the widespread availability and overprescription of highly addictive medications. The series revolves around Richard Sackler (portrayed by Matthew Broderick), who strategically used Purdue Pharma to transform the painkiller OxyContin into a blockbuster drug, with little regard for its escalating presence on the black market. While fictionalized, “Painkiller” draws from real-life events and figures, notably referencing the Sackler family, although it only scratches the surface of the catastrophic consequences of opioid abuse.

The series, initially inspired by Patrick Radden Keefe’s influential article in The New Yorker, “The Family That Built an Empire of Pain,” and his 2021 novel of the same name, weaves in elements from Barry Meier’s 2003 nonfiction work, “The Origin of America’s Opioid Epidemic,” to underline the psychological impacts of addiction. Characters like opioid addict Glen Kryger (played by Taylor Kitsch), his wife Lily, and son Tyler were created to illustrate the profound effects of opioid abuse. Each episode begins with a disclaimer, acknowledging its basis in real events and its dramatization for narrative purposes, often incorporating interviews with real victims to underscore the parallels to reality.

The series chronicles the history of the Sackler family accurately, portraying their significant role in Purdue Pharma’s pharmaceutical pursuits. Arthur Sackler’s impactful involvement in the medical scene, particularly his marketing strategies for drugs, set the stage for the subsequent actions of his brothers, Raymond and Mortimer, and eventually Richard, who spearheaded Purdue Pharma’s research on OxyContin.


Despite concerns regarding OxyContin’s addictive nature, Purdue Pharma pushed its sales aggressively, emphasizing the strength of doses and heavily marketing the drug. The exponential rise in opioid availability led to widespread addiction and a surge in black market distribution. Legal repercussions ensued, with Uzo Aduba’s character, Edie Flowers, representing a blend of federal investigators involved in prosecuting Purdue Pharma for misrepresenting OxyContin’s dangers.

The Sackler family settled cases and faced lawsuits linking them directly to the surge in opioid-related deaths. Purdue Pharma’s bankruptcy furthered the controversy, with ongoing legal battles and increased public awareness challenging the Sacklers’ association with the crisis. Despite the series’ portrayal, recent developments such as a $6 billion settlement and legal battles following Purdue Pharma’s bankruptcy continue to shape the narrative.

“Painkiller” joins the league of creative projects aiming to capture the complexity and devastation of the opioid crisis. Notably, the series adds to a landscape that includes similar portrayals like Hulu’s Emmy-winning “Dopesick,” offering nuanced perspectives on the Sackler family’s involvement and the catastrophic fallout of opioid abuse.